If you've already removed any then that alone could be the source of your problem.
And of all SL mods good ol' SD is the beast of beasts.
I doubt it is because of my gaming Rig, It's good, with all the top texture mods I still get 60 FPS.
There is a shrine in which bears the appearance of Sanguine.
Find what you really can't live without, add those at the beginning of a play through, then play.
Throwing SL mods into the mix is just too much for the game or your system.